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KMID : 0624620090420060324
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BMB Reports
2009 Volume.42 No. 6 p.324 ~ p.330
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Autophagy in neurodegeneration: two sides of the same coin
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Lee Jin-A
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Abstract
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Autophagy is a bulk lysosomal degradation process important in development, differentiation and cellular homeostasis in multiple organs. Interestingly, neuronal survival is highly dependent on autophagy due to its post-mitotic nature, polarized morphology and active protein trafficking. A growing body of evidence now suggests that alteration or dysfunction of autophagy causes accumulation of abnormal proteins and/or damaged organelles, thereby leading to neurodegenerative disease. Although autophagy generally prevents neuronal cell death, it plays a protective or detrimental role in neurodegenerative disease depending on the environment. In this review, the two sides of autophagy will be discussed in the context of several neurodegenerative diseases.
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KEYWORD
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Autophagy, Cell death, Cell survival, Neurodegeneration
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